Pharmacology

Posts on the various pharmacologic therapies in use in the operating room (OR) and intensive care unit (ICU).

  • Rifampin

    Rifampin is the most commonly used oral/IV antibiotic among the rifamycins (rifabutin, rifapentine, etc.) Rifampin acts at the level of…

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  • Procainamide

    Procainamide is a type IA antiarrhythmic which prolongs repolarization via sodium channel blockade. This is achieved by slowing conduction through…

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  • Fluconazole

    Fluconazole (Diflucan) is an intravenous and oral antifungal medication that inhibits ergosterol synthesis (an important component of fungal cell membranes).…

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  • Unasyn

    Unasyn (ampicillin-sulbactam) is an intravenous antibiotic that I most often use for ENT-related infections/prophylaxis but sometimes gynecologic and intraabdominal infections…

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  • Dopamine In Shock And Kidney Injury

    In pursuit of evidence-based rationales for my hatred of dopamine, I turned to PubMed and queried the database for “dopamine…

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  • Midodrine

    Midodrine (ProAmantine) is an oral and intravenous prodrug. Its active metabolite, desglymidodrine, activates α-1 receptors to produce vaso and venoconstriction…

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  • Desmopressin (DDAVP)

    Desmopressin (DDAVP, antidiuretic hormone) is a synthetic analog of vasopressin which can be administered IV, IM, subQ, and orally. Compared…

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  • Nitric Oxide

    Nitric oxide is a molecule normally made by vascular endothelial cells to decrease vascular resistance in both the systemic and…

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  • Lefamulin

    Lefamulin (Xenleta) is an intravenous and oral antibiotic approved for community acquired bacteria pneumonia (CABP). Similar to antibiotics like clindamycin…

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  • Treprostinil

    Treprostinil (Remodulin) is an IV, SC, PO, and inhaled prostaglandin I2 analog used to treat pulmonary arterial hypertension (PAH) by…

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