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Malignant Hyperthermia

Malignant hyperthermia (MH) is a rare, autosomal dominant condition involving mutations in the ryanodine receptor type 1 (RYR-1) causing an aberrant calcium-induced calcium release (CICR)...

Acetaminophen NAPQI Toxicity

A simple overview of acetaminophen (Tylenol) toxicity:Acetaminophen (Tylenol) is typically metabolized into nontoxic products by means of sulfation and glucoronidation (blue and green paths,...

Context-Sensitive Half-Time

In any basic pharmacology course, we're taught the concept of an "elimination half-life", or the time it takes to reach 50% of a drug's...

Vasopressin – The Forgotten Pressor

Vasopressin, otherwise known as antidiuretic hormone (ADH), is a peptide hormone synthesized in the hypothalamus and released by the posterior pituitary gland. Its physiologic...

Treating A Number With Bicarbonate

Once a patient's arterial pH falls below ~7.10, many of our resuscitative measures (namely vasoactive agents) fail in the face of worsening acidemia. While...

ABOUT RISHI

I'm a combined clinical fellow in critical care medicine and cardiothoracic anesthesiology at Harvard looking to improve medical education and patient safety with technology and quality initiatives.