Home Tags Pharmacology

Tag: pharmacology

Malignant Hyperthermia

Malignant hyperthermia (MH) is a rare, autosomal dominant condition involving mutations in the ryanodine receptor type 1 (RYR-1) causing an aberrant calcium-induced calcium release (CICR)...

Acetaminophen NAPQI Toxicity

A simple overview of acetaminophen (Tylenol) toxicity:Acetaminophen (Tylenol) is typically metabolized into nontoxic products by means of sulfation and glucoronidation (blue and green paths,...

Context-Sensitive Half-Time

In any basic pharmacology course, we're taught the concept of an "elimination half-life", or the time it takes to reach 50% of a drug's...

Vasopressin – The Forgotten Pressor

Vasopressin, otherwise known as antidiuretic hormone (ADH), is a peptide hormone synthesized in the hypothalamus and released by the posterior pituitary gland. Its physiologic...

Treating A Number With Bicarbonate

Once a patient's arterial pH falls below ~7.10, many of our resuscitative measures (namely vasoactive agents) fail in the face of worsening acidemia. While...

ABOUT RISHI

Anesthesiology chief resident physician at Baylor College of Medicine and future combined fellow in critical care and cardiothoracic anesthesiology at Harvard looking to improve medical education and patient safety with technology and quality initiatives.