Tag: antidote

  • Dantrolene

    Dantrolene

    Dantrolene (RYANODEX) is an intravenous nanosuspension of dantrolene sodium used as a prophylactic and therapeutic agent to treat malignant hyperthermia (MH) – a life-threatening condition triggered by succinylcholine and halogenated volatile anesthetic gases creating sustained skeletal muscle contraction due to a defect in the release/reuptake of calcium. Dantrolene works by…

    Read More

  • Flumazenil

    Flumazenil

    Flumazenil (Romazicon) is a reversal agent for benzodiazepines (“benzos”) through competitive inhibition at the GABA(A)/benzo receptor complex. Since it serves as an antidote for benzos, we have to consider the effects of acute withdrawal – anxiety, agitation, and even lowering the threshold for seizures. Similar to naloxone for opioid reversal,…

    Read More