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Transexamic Acid

Tranexamic acid (“TXA”, Cyklokapron) is an analog of the amino acid lysine that works as an antifibrinolytic by binding lysine receptor sites on plasminogen to competitively inhibit its conversion to plasmin - the enzyme responsible for…
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Isoproterenol

Isoproterenol (Isuprel) is a nonselective beta adrenergic agonist structurally very similar to epinephrine which I use most commonly in the electrophysiology (EP) lab to induce tachyarrhythmias for the electrophysiologist to map out and…
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Diphenhydramine

Diphenhydramine (Benadryl) is a first generation antihistamine which blocks H1 histamine receptors. Unlike many second generation antihistamines, first generation medications like diphenhydramine cross the blood-brain barrier and inhibit…
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iPhone XS Max

After my critical care boards yesterday, I went to "reward" myself by upgrading my iPhone X to the iPhone XS Max. When I was an Android user, I always enjoyed the larger form factor handsets (Pixel 2 XL, Samsung Note, etc.), and now I can…
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Propofol

Propofol (Diprivan) is perhaps the most well known intravenous hypnotic used in perioperative and intensive care medicine. This "milk of amnesia" is prepared in a lecithin-based (purified egg yolk) emulsion. Similar to many other IV…
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Bispectral Index (BIS) Monitor

The bispectral index (BIS) monitor is a noninvasive derivative of the electroencephalogram (EEG) used to assess the depth of anesthesia to help prevent intraoperative awareness - a rare (~ 0.1% of general anesthetics) but serious…
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ABOUT DR. RISHI

Adult cardiothoracic anesthesiology fellow, ICU attending, and board certified anesthesiologist at Harvard looking to improve medical education, diagnostics, and patient safety while promoting team-based, patient-centered care.

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