Basal/Bolus vs Sliding Scale Insulin In The Hospital

The overwhelming majority of the patients I've encountered on the wards have diabetes mellitus (DM). While there are countless ways to manage DM as an outpatient (insulin injections, biguanides, sulfonylureas, etc.), sliding scale insulin...

Aldactone and Lasix in Cirrhosis

After all the patients I've seen with ascites secondary to hepatic cirrhosis, I wondered why we tend to start them on 100 mg Aldactone (spironolactone) with a 40 mg Lasix (furosemide) adjuvant. What's the...

Pradaxa vs Coumadin – Reducing Stroke Risk in Atrial Fibrillation

Is Pradaxa (dabigatran etexilate) better at reducing the risk for stroke than Coumadin (warfarin) in patients with atrial fibrillation? For many years, Coumadin has been the oral anticoagulant of choice as prophylaxis against thrombus formation...

Treating Hepatitis C with Telaprevir

Hepatitis C virus (HCV), a liver infection which has been linked to cirrhosis and hepatocellular carcinoma, is a potentially chronic condition if left untreated. Because of its extremely long latency period, patients who have...

Disulfiram

Sometimes, medical therapy is just funny. Disulfiram, one of the drugs we had to learn for pharmacology months ago, is a treatment for chronic alcoholism. We're familiar with antibiotics working with the body's immune system...

Treating Lupus with Benlysta

A few months ago, Human Genome Services Inc. (NASDAQ: HGSI) and co-development partner GlaxoSmithKline revealed data from a phase III trial of Benlysta™, a promising new drug for treating systemic lupus erythematosus (SLE), otherwise...

Fighting BRCA Linked Cancer – PARP Inhibition

A recent Institute of Cancer Research study published in the New England Journal of Medicine describes a novel way of treating BRCA-gene based cancers. Mutations in the BRCA-1 and BRCA-2 genes are routinely linked...

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