antibiotic

Ertapenem

Ertapenem (Invanz) is an intravenous carbapenem antibiotic. Compared to meropenem, ertapenem has a more limited spectrum of activity, notably lacking activity against Pseudomonas, Acinetobacter, and Enterococcus - some very important healthcare-associated organisms. Furthermore, it's...

Clindamycin

Clindamycin is an oral and intravenous antibiotic that works by inhibiting the 50S ribosomal subunit required for bacterial protein synthesis. It has excellent activity against gram-positive cocci (e.g., Streptococcus and Staphylococcus, limited coverage of...

Cefoxitin

Cefoxitin (Mefoxin) is an intravenous cephamycin antibiotic (sometimes classified as a second-generation cephalosporin subgroup) that binds penicillin-binding proteins thereby disrupting the formation of bacterial cell walls. Compared to first-generation cephalosporins like cefazolin, cefoxitin is...

Gentamicin

Gentamicin is an intravenous, intramuscular, and topical aminoglycoside bactericidal antibiotic that works by interfering with bacterial protein synthesis. By binding the 30S subunit of the bacterial ribosome, proteins are improperly translated leading to bacterial...

Polymyxin B

Polymyxin B is a "last-line" antibiotic primarily used to treat hospital-acquired gram-negative infections that are resistant to essentially all other conventional antibiotics. As an intensivist, I've had to use polymyxin B for two very...

Avycaz

Ceftazidime-avibactam (Avycaz) is an intravenous antibiotic combining a third-generation cephalosporin (inhibits cross-linking of peptidoglycan used to form the bacterial cell wall) with a β-lactamase inhibitor (inhibits a bacterial enzyme which degrades β-lactam antibiotics). Avycaz is used...

Tigecycline

Tigecycline (Tygacil) is an intravenous glycylcycline antibiotic used to treat a variety of skin/soft tissue infections, complicated intra-abdominal infections, and community-acquired pneumonia (NOT hospital/ventilator-acquired pneumonia). Glycylcyclines are structurally similar to tetracyclines with less antibiotic resistance...

Doxycycline

Doxycycline is an oral and intravenous bacteriostatic tetracycline antibiotic which binds to the 30S bacterial ribosomal subunit rendering protein synthesis ineffective. This class of antibiotics has a broad range encompassing some coverage for MRSA,...

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