steroids

How Do Steroids Cause Immunosuppression?

Glucocorticoids (GCs, "steroids") are routinely used to induce immunosuppression in patients who have received transplants or have autoimmune diseases. However, we often see an increase in the measured white blood cell (WBC) count after...

Hydrocortisone

Hydrocortisone (Solu-Cortef) is a pharmacologic analog of the steroid hormone cortisol (identical structure) that serves as a reference to gauge the relative mineralcorticoid and glucocorticoid potencies of other steroids. This is similar to how...

Dexamethasone

Dexamethasone (Decadron) is synthetic adrenocortical steroid roughly 25 times more potent than hydrocortisone and devoid of mineralcorticoid (“sodium retaining”) properties. Therefore, it's primarily used for long acting, anti-inflammatory effects. In the ICU, I most commonly...

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