Factor eight inhibitor bypass agent (FEIBA) is a plasma derived procoagulant that contains primarily factors II (prothrombin) and activated factor X (final common pathway for the extrinsic and intrinsic pathways). It also contains factors IX and VIIa. FEIBA controls bleeding by facilitating the generation of thrombin through the prothrombinase complex.
FEIBA has been FDA approved for use in patients with hemophilia A and B with inhibitors to control/prevent bleeding and as part of perioperative management. Inhibitors are antibodies against clotting factors that these patients often receive throughout their lives in addition to what they produce. The cardiothoracic surgeons and anesthesiologists often reach a consensus to use FEIBA off-label in patients at high risk for bleeding, and anecdotally, I’ve had pretty good success with it using ~500 units.
As with all procoagulants, one must also consider the risk of thrombosis! The recommendation is NOT to use FEIBA in tandem with other agents like antifibrinolytics (tranexamic acid, aminocaproic acid, etc.)
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