coagulopathy
Education
P2Y12/PRU “Plavix Effect” Assay
P2Y12 receptor inhibitors like clopidogrel (Plavix), prasugrel (Effient), and ticagrelor (Brilinta) are powerful antiplatelet agents to promote anticoagulation in patients with acute coronary syndrome, peripheral artery disease, etc. Therefore, we often stop P2Y12 inhibitors...
Rishi -
Medical
Desmopressin (DDAVP)
Desmopressin (DDAVP, antidiuretic hormone) is a synthetic analog of vasopressin which can be administered IV, IM, subQ, and orally. Compared to vasopressin (generally regarded as a potent vasoconstrictor), DDAVP has less efficacy as a...
Rishi -
Education
Disseminated Intravascular Coagulation (DIC)
Disseminated intravascular coagulation (DIC) is a life-threatening condition (hence the popular alternative definition of "death is coming") affecting the coagulation cascade. Typically, clot formation and fibrinolysis are carefully balanced by various mechanisms; however, in...
Rishi -
Medical
Tranexamic Acid
Tranexamic acid (“TXA”, Cyklokapron) is an analog of the amino acid lysine that works as an antifibrinolytic by binding lysine receptor sites on plasminogen to competitively inhibit its conversion to plasmin - the enzyme...
Rishi -