coagulopathy
Pharmacology
Cangrelor
Cangrelor (Kengreal) is an intravenous P2Y12 platelet inhibitor which is run as a continuous infusion. Unlike clopidogrel (Plavix) which is a prodrug requiring conversion to an active metabolite, cangrelor is already active and has...
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Education
P2Y12/PRU “Plavix Effect” Assay
P2Y12 receptor inhibitors like clopidogrel (Plavix), prasugrel (Effient), and ticagrelor (Brilinta) are powerful antiplatelet agents to promote anticoagulation in patients with acute coronary syndrome, peripheral artery disease, etc. Therefore, we often stop P2Y12 inhibitors...
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Medical
Desmopressin (DDAVP)
Desmopressin (DDAVP, antidiuretic hormone) is a synthetic analog of vasopressin that can be administered IV, IM, subQ, and orally. Compared to vasopressin (generally regarded as a potent vasoconstrictor), DDAVP has less efficacy as a...
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Education
Disseminated Intravascular Coagulation (DIC)
Disseminated intravascular coagulation (DIC) is a life-threatening condition (hence the popular alternative definition of "death is coming") affecting the coagulation cascade. Typically, clot formation and fibrinolysis are carefully balanced by various mechanisms; however, in...
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