coagulopathy
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Education
P2Y12/PRU “Plavix Effect” Assay
P2Y12 receptor inhibitors like clopidogrel (Plavix), prasugrel (Effient), and ticagrelor (Brilinta) are powerful antiplatelet agents to promote anticoagulation in patients…
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Pharmacology
Desmopressin (DDAVP)
Desmopressin (DDAVP, antidiuretic hormone) is a synthetic analog of vasopressin which can be administered IV, IM, subQ, and orally. Compared…
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Education
Disseminated Intravascular Coagulation (DIC)
Disseminated intravascular coagulation (DIC) is a life-threatening condition (hence the popular alternative definition of “death is coming”) affecting the coagulation…
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Pharmacology
NovoSeven
NovoSeven (recombinant factor VIIa or rFVIIa) is an intravenous, structurally similar molecule to human factor VII – a protein involved…
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Pharmacology
Alteplase
Alteplase (recombinant tissue plasminogen activator, tPA) is a potent intravenous fibrinolytic (“clot buster”) used for everything from acute ischemic strokes…
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Pharmacology
RiaSTAP
RiaSTAP is a fibrinogen concentrate made from pooled human plasma (may not be an option in Jehovah’s Witness patients). It…
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Pharmacology
Tranexamic Acid
Tranexamic acid (“TXA”, Cyklokapron) is an analog of the amino acid lysine that works as an antifibrinolytic by binding lysine…
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Pharmacology
Factor Eight Inhibitor Bypass Agent (FEIBA)
Factor eight inhibitor bypass agent (FEIBA) is a plasma derived procoagulant that contains primarily inactivated factors II (prothrombin), IX, and…
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Pharmacology
Heparin
Heparin is a naturally occurring, negatively charged carbohydrate consisting of molecules with different lengths (unfractionated). It potentiates the activity of…
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Pharmacology
Kcentra
Kcentra (human prothrombin complex concentrate) is a medication derived from human plasma that contains unactivated factors II, VII, IX, X,…
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