Disseminated intravascular coagulation (DIC) is a life-threatening condition (hence the popular alternative definition of “death is coming”) affecting the coagulation cascade. Typically, clot formation…
NovoSeven (recombinant factor VIIa or rFVIIa) is an intravenous, structurally similar molecule to human factor VII – a protein involved in the extrinsic pathway…
Alteplase (recombinant tissue plasminogen activator, tPA) is a potent intravenous fibrinolytic (“clot buster”) used for everything from acute ischemic strokes and clearing central line…
RiaSTAP is a fibrinogen concentrate made from pooled human plasma (may not be an option in Jehovah’s Witness patients). It was FDA approved for…
Tranexamic acid (“TXA”, Cyklokapron) is an analog of the amino acid lysine that works as an antifibrinolytic by binding lysine receptor sites on plasminogen…
Factor eight inhibitor bypass agent (FEIBA) is a plasma derived procoagulant that contains primarily inactivated factors II (prothrombin), IX, and X. Additionally, it contains…