Zerbaxa (ceftolozane-tazobactam) is a potent intravenous antibiotic used for gram-negative intraabdominal and urinary tract infections resistant to more traditional antibiotics. It is active against P. aeruginosa, E. coli, and various other gram negative bugs like species of Proteus, Citrobacter, Serratia, and Salmonella.

As an intensivist, I’ve most commonly prescribed Zerbaxa for complicated cases of pyelonephritis and in combination with metronidazole for complex abdominal sepsis.

The cephalosporin portion of this medication (ceftolozane) inhibits assembly of the bacterial cell wall making it a bactericidal antibiotic. Tazobactam helps irreversibly inhibit enzymes (namely beta-lactamases) produced by certain bacteria that degrade common penicillins/cephalosporins thereby protecting ceftolozane.

Drop me a comment below with questions! 🙂

Related Articles

One Comment

  1. Hello sir ,

    My father has been prescribed this drug Zerbaxa for pseudomonas bacterial infection in lungs. My father has been in icu since month for post COVID lung fibrosis.
    Could you pls assist where can I get this drug at the earliest ?

Leave a Reply

Your email address will not be published. Required fields are marked *

Back to top button