Doxycycline

Doxycycline is an oral and intravenous bacteriostatic tetracycline antibiotic which binds to the 30S bacterial ribosomal subunit rendering protein synthesis ineffective. This class of antibiotics has a broad range encompassing some coverage for MRSA,...

Rifampin

Rifampin is the most commonly used oral/IV antibiotic among the rifamycins (rifabutin, rifapentine, etc.) Rifampin acts at the level of RNA transcription by inhibiting bacterial DNA-dependent RNA polymerase. This drug has excellent oral bioavailability...

Procainamide

Procainamide is a type IA antiarrhythmic which prolongs repolarization via sodium channel blockade. This is achieved by slowing conduction through the ventricular His-Purkinje system thereby widening the QRS complex (and ultimately the QT interval). As...

Reversal With Sugammadex Versus Neostigmine – Postoperative Pulmonary Complications (STRONGER)

Postoperative pulmonary complications (PPCs) come in a wide variety of flavors ranging from atelectasis and pulmonary congestion to respiratory failure and pneumonia. Not only do certain surgeries (upper abdominal and thoracic), age, case duration,...

Fluconazole

Fluconazole (Diflucan) is an intravenous and oral antifungal medication that inhibits ergosterol synthesis (an important component of fungal cell membranes). As an intensivist, I most often use this medication to cover Candida albicans infections...

Unasyn

Unasyn (ampicillin-sulbactam) is an intravenous antibiotic that I most often use for ENT-related infections/prophylaxis but sometimes gynecologic and intraabdominal infections as well (Zosyn being another common alternative). Ampicillin, a beta-lactam, is often times degraded by...

RK.md’s Perioperative And Critical Care Reference Sheet

Ever since finishing my fellowships, I wanted to create a free reference sheet (front and back) containing "high yield" information in the areas of critical care and perioperative medicine. I feel I'm well suited...

Dopamine In Shock And Kidney Injury

In pursuit of evidence-based rationales for my hatred of dopamine, I turned to PubMed and queried the database for "dopamine shock" filtered for meta-analyses, randomized controlled trials, and systematic reviews in adult patients since...

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