Factor eight inhibitor bypass agent (FEIBA) is a plasma derived procoagulant that contains primarily inactivated factors II (prothrombin), IX, and X. Additionally, it contains activated factor VII. FEIBA controls bleeding by facilitating the generation of thrombin through the prothrombinase complex.
Heparin is a naturally occurring, negatively charged carbohydrate consisting of molecules with different lengths (unfractionated). It potentiates the activity of antithrombin (AT) III which inactivates thrombin and factor Xa based on the size of the heparin molecule. Fractionated, low molecular weight forms of heparin (ie, enoxaparin) are more selective for…
Kcentra (human prothrombin complex concentrate) is a medication derived from human plasma that contains unactivated factors II, VII, IX, X, protein C, protein S, antithrombin III, and heparin. In 2013, it gained FDA approval for the urgent reversal of acquired factor deficiency from vitamin K antagonism (ie, Coumadin) in the…