coagulopathy

Tranexamic acid (“TXA”, Cyklokapron) is an analog of the amino acid lysine that works as an antifibrinolytic by binding lysine receptor sites on plasminogen to competitively inhibit its conversion to plasmin - the enzyme...

Factor eight inhibitor bypass agent (FEIBA) is a plasma derived procoagulant that contains primarily inactivated factors II (prothrombin), IX, and X. Additionally, it contains activated factor VII. FEIBA controls bleeding by facilitating the generation...

Heparin is a naturally occurring, negatively charged carbohydrate consisting of molecules with different lengths (unfractionated). It potentiates the activity of antithrombin (AT) III which inactivates thrombin and factor Xa based on the size of...

Kcentra (human prothrombin complex concentrate) is a medication derived from human plasma that contains unactivated factors II, VII, IX, X, protein C, protein S, antithrombin III, and heparin. In 2013, it gained FDA approval...