Browsing Category

Lessons

Malignant Hyperthermia

Malignant hyperthermia (MH) is a rare, autosomal dominant condition involving mutations in the ryanodine receptor type 1 (RYR-1) causing an aberrant calcium-induced calcium release (CICR) mechanism. With normal skeletal muscle contraction,…
Read More...

Context-Sensitive Half-Time

In any basic pharmacology course, we're taught the concept of an "elimination half-life", or the time it takes to reach 50% of a drug's initial concentration. With more advanced multi-compartmental models of pharmacokinetics, the concept of…
Read More...

Lactate And Sepsis

It's always interesting to see how practitioners interpret the utility of lactate. Some find it completely useless, others think it's a marker of poor oxygen delivery, and a decent number trend lactates as a way to measure the response to…
Read More...

Expanding Neck Hematoma Management

Neck hematomas are a life threatening albeit rare post operative complication of surgeries in the cervical spine and neck (thyroidectomy, carotid endarterectomy, etc.) The overwhelming majority of patients who undergo these types of…
Read More...