Ventricular assist devices (VADs) can support the right (RVAD) and left (LVAD) ventricles and were initially utilized as mechanical circulatory support devices for bridge-to-transplant (BTT) in heart failure. Modern continuous flow VADs are also being used for destination therapy (DT) for those who are not candidates for cardiac transplantation or are too ill to wait for a donor. The options available for advanced heart failure therapy are growing each year, so healthcare providers are increasingly likely to encounter patients with VADs. What are some basic things we should know? This article will focus on LVADs.
Continuous flow VADs like the Heartmate II and III have a motor that spins 5,000-10,000 times per minute! This rotary action propels blood flow from the inflow cannula (typically the apex of the left ventricle, LV) to the outflow cannula (proximal aorta) and the rest of the body. Because of the constant flow, patients may not have a palpable pulse depending on their underlying ventricular function and aortic valve activity.
LVADs assist the LV by promoting forward systemic flow. It’s important to keep right heart failure in mind and consider pulmonary vasodilators with inotropic support of the right ventricle (RV) if needed. Remember, a significant portion of RV systolic function hinges on LV function. If the LV does not have to do much work anymore because of the LVAD, the RV could fail.
Pump speed (as RPM) is the only variable programmed by an operator, but a VAD machine will display other parameters:
- Power – basically the energy needed to create flow. An acute increase in power requirements could be related to thrombosis within the LVAD and warrants additional anticoagulation and/or thrombolytics consideration.
- Flow – a surrogate for the cardiac output. For a fixed RPM, a higher flow rate implies decreased resistance, as in sepsis or vasodilation. A lower flow suggests decreased intravascular volume (i.e., hypovolemia or bleeding). Flow is related to the power, pump speed, patient’s blood viscosity, and pressure differential across the pump.
- Pulsatility index (PI) – represents the balance of native ventricular function and unloading by the continuous flow VAD. An increase could suggest recovery of ventricular function, whereas a decrease represents hypovolemia, worsening ventricular function, or increased pump speed causing more ventricular unloading and less pulsatility.
We also have to consider other things in patients requiring VAD support:
- These patients require anticoagulation and are pre-disposed to clot formation due to stasis within the native heart, especially around the aortic valve. Therefore, lookout for signs of embolic phenomena.
- Dysrhythmias are often caused by the inflow cannula irritating the ventricular septum. Fluid resuscitation and slowing the pump speed can allow the ventricle to fill more and alleviate this suction effect.
- Aortic insufficiency (“regurgitation”) is fairly common the longer VADs stay in, and this can actually create a loop within the VAD. Left ventricle → VAD inflow → VAD outflow → aorta → back into the left ventricle through an incompetent aortic valve.
- Hemolysis from physical agitation of red blood cells making contact with the rotor pump. Monitor carefully whenever the pump speed is adjusted.
- Infections can occur in the VAD driveline or the pocket housing the pump (depending on the VAD). Typical organisms include Staphylococcus, Enterococcus, and Pseudomonas. Empiric antibiotics should be initiated, and sometimes surgical debridement is required for deeper wound infections.
- Arrest: In the event of cardiopulmonary arrest, if the VAD is still functional, typically, a “chemical code” is warranted after investigation of the VAD and possible causes of, for example, hypotension. If the VAD function has truly stopped or is not functioning appropriately with resulting hypotension, external chest compressions are recommended.