infection

Isavuconazonium (Cresemba)

Isavuconazonium (Cresemba) is an oral and intravenous antifungal agent used to treat invasive aspergillosis and mucormycosis in adult patients by disrupting fungal cell membrane formation. After it is converted to isavuconazole in the plasma,...

Fungal Endocarditis

Fungal endocarditis (inflammation of the heart's inner lining) is most commonly caused by Candida species and is associated with a high mortality rate. Risk factors include long-term antibiotic therapy (especially with indwelling central lines), immunosuppression, prosthetic...

Pfizer-BioNTech COVID-19 Vaccine: Ingredients And My Symptoms Afterwards

I'm thankful I was in group 1A for my hospital system's vaccine roll-out. I received my first dose of the Pfizer-BioNTech COVID-19 vaccine on December 18, 2020 followed by my second dose exactly three...

How mRNA Vaccines Work – Gene Transcription And Translation

Conventional vaccines typically involve growing a virus in various cell lines, injecting a part of the virus into the host, and relying on the host to mount an immunologic response (ie, create antibodies and...

How Do N95 Masks Work?

N95 masks have become one of the most coveted pieces of personal protective equipment (PPE) during the COVID-19 pandemic; however, the mechanism by which these masks capture particles has very little to do with...

HCQ Or Chloroquine +/- Macrolide For COVID-19

This observational Lancet study compared ~96,000 patients across 671 international hospitals with a positive COVID-19 diagnosis who received hydroxychloroquine (HCQ) +/- a macrolide (ie, azithro) or chloroquine +/- a macrolide (four total treatment arms)...

Fluconazole

Fluconazole (Diflucan) is an intravenous and oral antifungal medication that inhibits ergosterol synthesis (an important component of fungal cell membranes). As an intensivist, I most often use this medication to cover Candida albicans infections...

Influenza Vaccine

The seasonal influenza ("flu") vaccine is recommended for all people ≥ 6 months old who don't have a contraindication (including pregnant women regardless of trimester) and is typically administered from late October through April...

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